THE DOCTOR · PUBLICATIONS
Scientific Publications, Independent Citations and Patents
Prof. Dr. Yalçın Karakoca · Last updated: 25 September 2026
Publications in the ORCID record
ORCID iD: 0000-0002-0682-5738This list is retrieved automatically from the doctor’s ORCID record; when the record is updated, this list is updated too. The sections below contain plain-language summaries of the publications, with PDF and PubMed links.
Source: orcid.org public record · ORCID is an international registry that links researchers and their publications through a persistent identification number.
Publications indexed in PubMed
- Karakoca Y, Karaagac G, Aydemir C, Caner C. A new endoluminal resection technique and device: resector balloon. The Annals of Thoracic Surgery. 2008;85(2):628-631. doi:10.1016/j.athoracsur.2007.07.019 · PMID 18222279. — First description of the device and the technique; 38 interventions in 30 patients in 2006; mechanical resection of endobronchial tumour and granulation tissue, control of bleeding and dilatation. PDF PubMed
- Karakoca Y, Karaagac G, Aydemir C. Therapeutic bronchoscopic intervention with resector balloon. Journal of Bronchology & Interventional Pulmonology. 2009;16(2):78-80. doi:10.1097/LBR.0b013e31819f273f · PMID 23168502. — 128 procedures in 112 consecutive patients; 100% technical success; no major complications. PDF PubMed
- Karakoca Y, Karaagac Gogus G, Yapicier O. Use of resector balloon desobstruction in patients with severe chronic obstructive pulmonary disease: a pilot feasibility study on a novel desobstruction technique. J Bronchology Interv Pulmonol. 2015;22(3):209-214. doi:10.1097/LBR.0000000000000178 · PMID 26165891. — 10 GOLD IV patients who had not responded to medical treatment; improvement in exercise capacity, SpO₂ and FEV1; no complications or exacerbations over 1–3 months. PDF PubMed
- Karakoca Y, Gogus G, Akduman S, Erturk B. Follow-up outcomes of chronic obstructive pulmonary disease patients who underwent dilatation and curettage with the Karakoca resector balloon: a 188-case series over 5 years. Medicine (Baltimore). 2018;97(48):e13400. doi:10.1097/MD.0000000000013400 · PMID 30508939 · PMC6283145. — 188 patients, GOLD III–IV; significant improvement in FEV1, SpO₂ and Borg score at week 1 and month 1 (P<0.001). PDF PubMed Full text – PMC
Non-indexed studies
Citations in independent reviews
- Hartman JE, Garner JL, Shah PL, Slebos DJ. New bronchoscopic treatment modalities for patients with chronic bronchitis. Eur Respir Rev. 2021;30:200281. (PMC9488715)
- Mayr AK, Valipour A. Modern bronchoscopic treatment options for patients with chronic bronchitis. J Clin Med. 2023;12(5):1854.
- Bronchoscopic Management of COPD and Advances in Therapy. Life. 2023;13(4):1036.
- Epithelial Resurfacing: The Bronchial Skin Peel. (PMC7462398)
Patents and registrations
- US patent US 11,833,318 B2: “Resector balloon with shock absorber padding and rigid or flexible catheter”. Date of patent: 5 December 2023. Inventor: Yalçın Karakoca. Patent document (PDF)
- European Union design registrations 006267597-0001 and 006267597-0002: Registration date: 26 February 2019; renewed in 2023, valid until 26 February 2029. Designer: Yalçın Karakoca. Registration certificate 0001 (PDF) · Registration certificate 0002 (PDF) · EUIPO record
- United Kingdom design registrations 90062675970001 and 90062675970002: Renewed on 14 February 2024, valid until 25 February 2029. Renewal certificate 0001 (PDF) · Renewal certificate 0002 (PDF)
- Karakoca Valve patent application: Filing date: 24 April 2025.
Congresses and presentations
The first international presentation of the method was given at the 16th World Congress for Bronchology (Tokyo); the other presentations are listed in the doctor’s academic CV (PDF).
ERS International Congress 2018 (Paris): Five years outcome of Karakoca Resector Balloon dilatation and curettage method in severe COPD, Eur Respir J 2018;52(Suppl 62):PA5394 · doi:10.1183/13993003.congress-2018.PA5394
International studies on lung valve treatment
Lung valve treatment for emphysema has been examined in international studies carried out in different countries. The studies below are the work of other research groups.
| Study | Design | Finding |
|---|---|---|
| STELVIO (N Engl J Med 2015) | 68 patients, randomised; patients without collateral ventilation | Significant improvement in FEV1, 6-minute walk and quality of life in the valve group |
| IMPACT (Am J Respir Crit Care Med 2016) | Homogeneous emphysema, randomised | Benefit also in selected patients with homogeneous emphysema |
| TRANSFORM (Am J Respir Crit Care Med 2017) | Heterogeneous emphysema, multicentre, randomised | Improvement in FEV1 and symptoms at 6 months |
| LIBERATE (Am J Respir Crit Care Med 2018) | 190 patients, 12 months, randomised | ≥15% increase in FEV1 in 47.7% of patients in the valve group (control 16.8%) |
| EMPROVE (Am J Respir Crit Care Med 2019) | A different valve, randomised | Improvement in FEV1 and quality of life |
| GOLD 2026 | Guideline | Endobronchial valves in selected patients with advanced emphysema: Evidence A |
These studies were carried out with specific commercial valves; results depend on the device, patient selection and the experience of the centre.
Study references:
- Klooster K et al. Endobronchial valves for emphysema without interlobar collateral ventilation (STELVIO). N Engl J Med. 2015;373(24):2325-2335.
- Valipour A et al. Endobronchial valve therapy in patients with homogeneous emphysema (IMPACT). Am J Respir Crit Care Med. 2016;194(9):1073-1082.
- Kemp SV et al. TRANSFORM. Am J Respir Crit Care Med. 2017;196(12):1535-1543.
- Criner GJ et al. LIBERATE. Am J Respir Crit Care Med. 2018;198(9):1151-1164.
- Criner GJ et al. EMPROVE. Am J Respir Crit Care Med. 2019;200(11):1354-1362.
- GOLD 2026 Report (bronchoscopic lung volume reduction).
Publication policy
The summaries on this page report the findings of the publications. The page is updated when new publications are added. Prof. Dr. Yalçın Karakoca is the inventor and patent holder of the Karakoca Resector Balloon, and the inventor and patent applicant for the Karakoca Valve.
PRELIMINARY ASSESSMENT
Is it suitable for you?
Book an appointment and bring your breathing test and chest CT scan reports. We decide together at the consultation. If you are coming from outside Istanbul, an online preliminary consultation can be held first.
Please bring: your breathing test, your chest CT scan report and images (CD/USB), your list of medicines and, if you have one, your blood gas test result.
APPOINTMENT
Book an appointment for a preliminary assessment
To find out whether you are suitable, book a preliminary assessment appointment. Bring your breathing test, chest CT scan report and list of medicines with you.
info@yalcinkarakoca.com · Rüzgarlıbahçe Mah. Cumhuriyet Cad. Hasoğlu Plaza Kat:3, Kavacık / Beykoz, İstanbul
This page is for general information purposes. It does not replace a medical examination or diagnosis. Treatment decisions are made during an examination, on an individual basis. In an emergency, call 112.
Medical content review: Prof. Dr. Yalçın Karakoca, Pulmonologist · Last updated: 25 September 2026